fluvastatin sodium salt
FLUVASTATIN SODIUM
CAS: 93957-55-2
Molecular Formula: C24H25FNNaO4
fluvastatin sodium salt - Names and Identifiers
| Name | FLUVASTATIN SODIUM |
| Synonyms | FLUVASTATIN NA FLUVASTATIN SODIUM fluvastatin sodium salt Fluvastatin sodium salt FLUVASTATIN SODIUM SALT (r*,s*-(e))-monosodiumsal(+-)-2-yl) 3,5-dihydro-7-(3-(4-fluorophenyl)-1-(1-methylethyl)-1h-indol-6-heptenoicaci sodium (3R,5S,6E)-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoate sodium (3S,5R,6E)-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoate sodium (3r,5s,6e)-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1h-indol-2-yl]-3,5-dihydroxy-6-heptenoate 5-dihydro-7-(3-(4-fluorophenyl)-1-(1-methylethyl)-1h-indol-2-yl)-monosodiumsalt,(r*,s*-(e))-(6-heptenoicaci |
| CAS | 93957-55-2 |
| EINECS | 1308068-626-2 |
| InChI | InChI=1/C24H26FNO4.Na/c1-15(2)26-21-6-4-3-5-20(21)24(16-7-9-17(25)10-8-16)22(26)12-11-18(27)13-19(28)14-23(29)30;/h3-12,15,18-19,27-28H,13-14H2,1-2H3,(H,29,30);/q;+1/p-1/b12-11+;/t18-,19-;/m1./s1 |
| InChIKey | ZGGHKIMDNBDHJB-RPQBTBOMSA-M |
fluvastatin sodium salt - Physico-chemical Properties
| Molecular Formula | C24H25FNNaO4 |
| Molar Mass | 433.45 |
| Melting Point | 194-197°C |
| Boling Point | 681.8°C at 760 mmHg |
| Flash Point | 366.1°C |
| Solubility | H2O: ≥9mg/mL |
| Vapor Presure | 1.6E-19mmHg at 25°C |
| Appearance | White to Brown Powder |
| Color | white to tan |
| Merck | 14,4218 |
| Storage Condition | 2-8°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months. |
| MDL | MFCD00929076 |
| Physical and Chemical Properties | Melting point 194~197 ℃. |
| In vitro study | Flublastin significantly inhibited the formation of thiobarbituric acid (TBA) reactive species in ferrous-initiated lipid peroxidation with an IC50 of 12 μm. 1 μm to 100 μm flublastin inhibits water-soluble and fat-soluble free radical generators 2,2 '-azobis (2-amidinopropane) dihydrochloride and 2,2'-azobis (2, 4-dimethylvaleronitrile)-induced peroxy radical-mediated lipid peroxidation. Flublastin (4 mM) and its metabolites have superoxide anion scavenging activity in the hypoxanthine-xanthine oxidase system, and have a strong scavenging effect on hydroxyl radicals produced by Fenton reaction. Flublastin (8 μm) and its metabolites act on CHL/IU cells, have a protective effect on DNA damage, and are as effective as the antioxidants Ascorbic acid, Trolox, and Probucol. Flublastin (100 nM) acts on human aortic smooth muscle cells (hASMC) to reduce the formation of superoxide anion radicals activated by angiotensin II in a dose-dependent manner. |
| In vivo study | Flublastin was administered to experimental rabbits at a dose of 10 mg/kg per day (fed with a diet containing 1.5% cholesterol) to lower blood lipids. The aorta of experimental rabbits (fed a diet containing 1.5% cholesterol) was administered with flublastin at a dose of 10 mg/kg per day, and the tissue ACE was significantly reduced. Daily administration of flublastin at a dose of 10 mg/kg to experimental rabbits (fed diet containing 1.5% cholesterol) significantly reversed the inhibition of acetylcholine-induced relaxation. |
fluvastatin sodium salt - Risk and Safety
| WGK Germany | 3 |
| RTECS | MJ9675050 |
| HS Code | 2933995300 |
fluvastatin sodium salt - Reference
| Reference Show more | 1. Liu Hongyan, Sun Chong, Li Qian, Liu Mei. Effects of Fluvastatin Sodium on proliferation, apoptosis and PI3K/AKT/mTOR pathway in cutaneous squamous cell carcinoma cells [J]. Journal of China Medical University, 2020,49(09):841-845. |
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